Publications | SMi Systems

Single Molecule Measurements

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Direct Measurement of Single-Molecule Ligand-Receptor Interactions

Journal of Physical Chemistry

Tracking Individual Membrane Proteins and Their Biochemistry: The Power of Direct Observation

Neuropharmacology

Photophysical Rate Constants and Oxygen Dependence for Si and Ge Rhodamine Zwitterions

Journal of Physical Chemistry

Thermodynamic Driving Forces of Redox Dependant CPR insertion into ER Biomimetic Membranes

Journal of Physical Chemistry

A Guide to Tracking Single Integral Membrane Proteins and Their Interactions in Supported Lipid Bilayers

Methods in Molecular Biology

Dissociation Constants of Cytochrome P450 2C9 / Cytochrome P450 Reductase Complexes in a Lipid Bilayer Membrane Depend on NADPH: A Single Protein Tracking Study

Journal of the American Chemical Society

Single Protein Tracking Reveals that NADPH Mediates the Insertion of Cytochrome P450-Reductase into a Biomimetic of the Endoplasmic Reticulum

Journal of the American Chemical Society

Substrate Dependent Native Luminescence from Cytochromes P450 3A4, 2C9, and P450cam

Journal of Physical Chemistry

Tracking Individual Membrane Proteins and Their Biochemistry: The Power of Direct Observation

Neuropharmacology

Conditions for Liposome Adsorption and Bilayer Formation on BSA Passivated Solid Supports

Chemistry and Physics of Lipids

Near Native Binding of a Fluorescent Serotonin Conjugate to Serotonin Type-3 Receptors

Bioorganic and Medicinal Chemistry Letters

The Effect of a Phase Transition on Single Molecule Tracks of Annexin V in Cushioned DMPC Assemblies

Soft Matter

Single Particle Tracking Reveals Corralling of a Transmembrane Protein in a Double-Cushioned Bilayer Assembly

Langmuir

Molecular Effects of a Nanocrystalline Quartz Support Upon Planar Lipid Bilayers

Langmuir

Nanoporous Microbead Supported Bilayers: Stability, Physical Characterization, and Incorporation of Functional Transmembrane Proteins

Langmuir

Stepping Statistics of Single HIV-1 Reverse Transcriptase Molecules During DNA Polymerization

Journal of Physical Chemistry

Photochemical Reactions of Rhodium(III) Diimine Complexes in Solid Glycerol Matrices. Ligand-Field Influences on Activation Energies

Coordination Chemical Reviews

The Thermodynamic Properties of Single Ion Channel Formation: Gramicidin

Journal of Physical Chemistry

Pharmacology

Evidence for an effect of receptor density on ligand occupancy and agonist EC₅₀

Scientific Reports

A Challenge finding P2X1 and P2X4 ligands

Neuropharmacology

The Binding Orientations of Structurally-Related Ligands Can Differ; A Cautionary Note

Neuropharmacology

The Muscarinic Antagonists Scopolamine and Atropine are Competitive Antagonists at 5-HT₃ Receptors

Neuropharmacology

Non-Competitive Inhibition of 5-HT₃ Receptors by Citral, Linalool and Eucalyptol Revealed by Non-Linear Mixed Effects Modelling

The Journal of Pharmacology and Experimental Therapeutics

A Fluorescent Approach for Identifying P2X1 Ligands

Neuropharmacology

A Review of Fluorescent Ligands for Studying 5-HT₃ Receptors

Neuropharmacology

Characterizing New Fluorescent Tools for Studying 5-HT₃ Receptor Pharmacology

Neuropharmacology

The Antimalarial Drug Proguanil is an Antagonist at 5-HT₃ Receptors

The Journal of Pharmacology and Experimental Therapeutics

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT₃A and 5-HT₃AB receptors

Neuropharmacology

Synthesis and characterisation of photoaffinity probes that target the 5-HT₃ receptor

Chimia

A Golden Approach to Ion Channel Inhibition

Trends in Pharmacological Sciences

Structure-Activity Relationships of Quinoxaline-Based 5-HT₃A and 5-HT₃AB Receptor-Selective Ligands

ChemMedChem

Discriminating between 5-HT₃A and 5-HT₃AB receptors

British Journal of Pharmacology

Recent Developments in 5-HT₃ Receptor Pharmacology

Trends in Pharmacological Sciences

Structural basis of ligand recognition in 5-HT₃ receptors

EMBO Reports

Design, synthesis and structure-activity relationships of highly potent 5-HT₃ receptor ligands

Journal of Medicinal Chemistry

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

Neuropharmacology

A single amino acid determines the toxicity of Ginkgo biloba extracts

ASEB Journal

VUF10166, a Novel Compound with Differing Activities at 5-HT ₃A and 5-HT₃AB Receptors

The Journal of Pharmacology and Experimental Therapeutics

High-affinity Fluorescent Ligands for the 5-HT₃ Receptor

Bioorganic & Medicinal Chemistry Letters

Cysteine Modification Reveals Which Subunits Form the Ligand Binding Site in Human Heteromeric 5-HT₃AB Receptors

Journal of Physiology

Ginkgolide B and Bilobalide Block the Pore of the 5-HT₃ Receptor at a Location that Overlaps the Picrotoxin Binding Site

Neuropharmacology

An Efficient and Information Rich Biochemical Method Design for Fragment Library Screening on Ion Channels

BioTechniques

Towards Biophysical Probes for the 5-HT₃ Receptor: Structure-Activity Relationship Study of Granisetron Derivatives

Journal of Medicinal Chemistry

Antimalarial Drugs Inhibit Human 5-HT₃ and GABA_A, but not GABA_C Receptors

British Journal of Pharmacology

The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT₃ receptors

British Journal of Pharmacology