Summaries
Read more on how our technology can impact your research area
Single molecule imaging allows scientists to understand the function of enzymes with unprecedented detail and to utilise them as reagents in novel single molecule assays. Here, we explore the unique value that this offers.
SMi Systems is developing a commercial analytics platform that automates single-molecule detection and analysis. Here we describe why single-molecule measurements are likely to become the go-to approach when developing novel drugs and vaccines.
SMi describes the differences between the regulatory considerations for research use only (RUO) products and those destined for in vitro diagnostics (IVD) use, and consider how risk management can be simultaneously applied.
SMi Systems is developing an analytics platform that utilises advanced optics and algorithms to automate detection of single molecules within a sample. We provide an overview of computational methods and why they are so important.
Single molecule analysis could transform drug development. Both the speed and quality of this process will be dramatically improved when there is a commercial single molecule platform that can accurately measure drug properties.
SMi Systems is developing a revolutionary benchtop instrument that probes drug interactions at single-molecule resolution. This is the story of how the groundbreaking innovation was inspired.
Accurate detection and quantification are the cornerstones of scientific and clinical research. Only the highest quality data enables informed decisions, but achieving this can conflict with time and financial constraints.
Single molecule imaging allows scientists to understand the function of enzymes with unprecedented detail and to utilise them as reagents in novel single molecule assays. Here, we explore the unique value that this offers.
SMi Systems is developing a commercial analytics platform that automates single-molecule detection and analysis. Here we describe why single-molecule measurements are likely to become the go-to approach when developing novel drugs and vaccines.
SMi describes the differences between the regulatory considerations for research use only (RUO) products and those destined for in vitro diagnostics (IVD) use, and consider how risk management can be simultaneously applied.
SMi Systems is developing an analytics platform that utilises advanced optics and algorithms to automate detection of single molecules within a sample. We provide an overview of computational methods and why they are so important.
Single molecule analysis could transform drug development. Both the speed and quality of this process will be dramatically improved when there is a commercial single molecule platform that can accurately measure drug properties.
SMi Systems is developing a revolutionary benchtop instrument that probes drug interactions at single-molecule resolution. This is the story of how the groundbreaking innovation was inspired.
Accurate detection and quantification are the cornerstones of scientific and clinical research. Only the highest quality data enables informed decisions, but achieving this can conflict with time and financial constraints.
Our Technology
SMi has developed a platform that consists of an instrument, consumables and software. These are integrated into a single system to provide an automated workflow.
Consumables are provided in standard 96 well formats and allow multiple molecular types to be detected and quantified in each of the individual wells.
Instruments provide a super-resolution detection of samples across an extremely large field of view. This allows the behaviour of hundreds of thousands of molecules to be simultaneous analysis.
Dedicated software automates the process so that users can focus on the data outputs rather than the means of achieving them.
Results
See how our technology has been used to address some important challenges
SMi’s platform can rapidly image large numbers of beads and count the particles on their surfaces.
There are two common approaches for the rapid analysis of analytes in a liquid sample: plate assays and bead assays. SMi can image single molecules on both.
Detection, identification and quantification are cornerstones of life sciences. SMi describes how it achieves this with its unique platform.
Being able to detect analytes is a critical aspect of drug discovery and diagnosis. Here we show how single molecule counting can increase assay sensitivity.
SMi Systems is developing a commercial analytics platform that automates single-molecule detection and analysis. Here we describe why single-molecule measurements are likely to become the go-to approach when developing novel drugs and vaccines.
SMi’s platform can rapidly image large numbers of beads and count the particles on their surfaces.
There are two common approaches for the rapid analysis of analytes in a liquid sample: plate assays and bead assays. SMi can image single molecules on both.
Detection, identification and quantification are cornerstones of life sciences. SMi describes how it achieves this with its unique platform.
Being able to detect analytes is a critical aspect of drug discovery and diagnosis. Here we show how single molecule counting can increase assay sensitivity.
SMi Systems is developing a commercial analytics platform that automates single-molecule detection and analysis. Here we describe why single-molecule measurements are likely to become the go-to approach when developing novel drugs and vaccines.